Table 3.
Distribution of clinical and genomic features in low and high TOP2A expression groups
| Low TOP2A | High TOP2A | P value | |
|---|---|---|---|
| (n=189) | (n=189) | ||
| Age | |||
| ≤ 45 years | 23% | 23% | 0.94 |
| 45–65 years | 62% | 67% | 0.34 |
| > 65 years | 15% | 10% | 0.2 |
| Nodal Status | |||
| 0 Positive | 55% | 51% | 0.48 |
| 1 Positive | 26% | 24% | 0.58 |
| 2–3 Positive | 19% | 25% | 0.14 |
| Grade | |||
| Well differentiated | 39% | 10% | <0.0001 |
| Moderately differentiated | 51% | 47% | 0.46 |
| Poorly differentiated | 10% | 44% | <0.0001 |
| Tumor Size | |||
| ≤ 2cm | 56% | 50% | 0.22 |
| 2–5 cm | 41% | 45% | 0.41 |
| > 5 cm | 3% | 5% | 0.31 |
| Standard Definitions | |||
| RS < 18 | 63% | 36% | <0.0001 |
| RS 18–30 | 33% | 34% | 0.79 |
| RS ≥31 | 4% | 30% | <0.0001 |
| TAILORx Definitions | |||
| RS < 11 | 24% | 13% | 0.005 |
| RS 11 – 25 | 63% | 44% | 0.0005 |
| RS > 25 | 13% | 43% | <0.0001 |