Table 4.

Estimated hazard ratios and 95% confidence intervals from joint models for recurrence rates

	Model I	P Value	Model II	P Value	Model III	P Value
Age 45–65 vs. >65	1.06 (0.45,2.49)		1.02 (0.44, 2.39)		1.02 (0.43,2.41)
Age ≤ 45 vs. >65	2.04 (0.82,5.09)	0.05	1.97 (0.80, 4.86)	0.05	2 (0.80,5.01)	0.05
Nodes 1 vs. 0	0.91 (0.51,1.62)		0.93 (0.52, 1.66)		0.89 (0.50,1.60)
Nodes 2–3 vs. 0	2.31 (1.46,3.65)	0.001	2.32 (1.46, 3.69)	0.002	2.21 (1.39,3.52)	0.003
Grade Mod. vs. Well	1.51 (0.75,3.03)		1.2 (0.59, 2.43)		1.28 (0.63,2.61)
Grade Poor vs. Well	3.14 (1.53,6.42)	0.002	1.95 (0.88, 4.32)	0.17	2.20 (0.98,4.93)	0.1
Tumor size >2 vs. ≤ 2 cm	1.15 (0.69,1.92)	0.6	1.08 (0.64, 1.80)	0.78	1.13 (0.68,1.88)	0.65
TOP2A x+5 vs. x			5.01 (1.53,16.43)	0.008
TOP2A High vs. Low					1.76 (0.98,3.15)	0.06