. Author manuscript; available in PMC: 2012 Jul 13.

Published in final edited form as: Clin Cancer Res. 2009 Dec 15;15(24):7693–7700. doi: 10.1158/1078-0432.CCR-09-1450

Table 5.

Five year recurrence rates by Recurrence Score and TOP2A expression

Recurrence Score	All Patients	Low TOP2A	High TOP2A	Relative Risk of 5-year Recurrence
				High vs. Low TOP2A
Standard Risk Group Definitions
RS <18	4.80% (3.4, 6.7)	3.20% (1.9, 5.3)	8.10% (5.0,12.8)	2.6 (95% CI 1.3, 5.2, P=0.008)
RS 18–30	14.60% (11.6, 18.2)	9.90% (6.6,14.5)	19.70% (15.0,25.5)	2 (95% CI 1.2, 3.2, P=0.004)
RS ≥ 31	14.50% (10.5, 19.8)	13.70% (5.4,30.2)	14.80% (10.4,20.8)	1.1 (95% CI 0.4, 2.7, P=0.86)
TAILORx Risk Group Definitions
RS <11	3.30% (1.7, 6.4)	0.90% (0.2, 3.8)	8.60% (4.3,16.5)	9.3 (95% CI 2.0, 44.4, P=0.005)
RS 11–25	10.20% (8.1, 12.6)	7.00% (5.0, 9.8)	15.30% (11.4,20.2)	2.2 (95% CI 1.4, 3.4, P=0.0005)
RS > 25	13.20% (10.1, 17.1)	9.60% (5.0,17.8)	14.40% (10.7,19.2)	1.5 (95% CI 0.75, 3.0, P=0.25)