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. 2012 Jul 13;2:509. doi: 10.1038/srep00509

Figure 3. Models of H-NS gene silencing mechanism based on nucleoprotein filament.

Figure 3

(a) Once a H-NS nucleoprotein filament is formed along RNA polymerase (RNAP) promoter site, it can block RNAP accessibility and cause gene silencing. (b) The H-NS nucleoprotein filament can also cause gene silencing by potentially obstructing the elongation process of a RNAP. (c) The H-NS nucleoprotein filament can mediate DNA hairpin formation by nucleoprotein filament mediated-DNA-bridging, which can then trap RNAP in the DNA hairpin loop to cause gene silencing.