Table 3.
Sensitivity, specificity and positive and negative likelihood ratios of EVLW/ABW, EVLW/PBW and EVLW/PBV for diagnosis of acute lung injury, acute respiratory distress syndrome or severe lung injury
| EVLW index | ALI | ARDS | sLI |
|---|---|---|---|
| EVLW/ABW | |||
| Sensitivity | 0.50 | 0.53 | 0.44 |
| Specificity | 0.85 | 0.83 | 0.76 |
| LR+ | 3.30 | 3.2 | 1.87 |
| LR- | 0.60 | 0.56 | 0.73 |
| Pretest odds | 0.55 | 0.42 | 0.21 |
| Posttest odds + | 1.80 | 1.33 | 0.40 |
| Posttest odds - | 0.32 | 0.23 | 0.16 |
| EVLW/PBW | |||
| Sensitivity | 0.61 | 0.60 | 0.67 |
| Specificity | 0.70 | 0.67 | 0.81 |
| LR+ | 2.02 | 1.80 | 3.50 |
| LR- | 0.56 | 0.60 | 0.41 |
| Pretest odds | 0.56 | 0.42 | 0.21 |
| Posttest odds + | 1.10 | 0.75 | 0.75 |
| Posttest odds - | 0.30 | 0.25 | 0.09 |
| EVLW/PBV | |||
| Sensitivity | 0.89 | 0.87 | 1.0 |
| Specificity | 0.52 | 0.47 | 0.88 |
| LR+ | 1.83 | 1.64 | 8.4 |
| LR- | 0.22 | 0.28 | 0 |
| Pretest odds | 0.55 | 0.42 | 0.21 |
| Posttest odds + | 1.00 | 0.68 | 1.79 |
| Posttest odds - | 0.12 | 0.12 | 0 |
ABW: actual body weight; ALI: acute lung injury; ARDS: acute respiratory distress syndrome; EVLW: extravascular lung water; LR-: negative likelihood ratio; LR+: positive likelihood ratio; PBV: pulmonary blood volume; PBW: predicted body weight; sLI: severe lung injury. Posttest odds given a positive (posttest odds +) or negative EVLW test (posttest odds -) are also shown. Positive EVLW tests were defined as EVLW/ABW > 10 ml/kg, EVLW/PBW > 10 ml/kg and EVLW/PBV > 1.5.