Table 2.
Prediction of the occurrence of acute kidney injury in univariate and multivariate regression analysis Univariate analysis
| Predictor | Hazard Ratio | P-value |
|---|---|---|
| Age (yrs) | HR 1.03 (95%CI 0.99-1.06) | 0.06 |
| Hx Heart Failure | HR 2.02 (95%CI 1.08-3.81) | 0.03 |
| Hx Chronic Kidney Disease | HR 2.15 (95%CI 1.16-3.99) | 0.02 |
| Steady State Creatinine > 110 μol/l | HR 2.21 (95%CI 1.16-4.23) | 0.02 |
| Outpatient Diuretic Treatment | HR 2.36 (95%CI 1.03-5.41) | 0.04 |
| Systolic Blood Pressure (mmHg) | HR 0.99 (95%CI 0.97-0.99) | 0.03 |
| Loop Diuretic Dose during first 72h | HR 1.00 (95%CI 1.00-1.01) | < 0.01 |
| Urea (mmo/l) | HR 1.09 (95%CI 1.04-1.15) | < 0.001 |
| Uric Acid (mmol/l) | HR 1.00 (95%Ci 1.00-1.00) | 0.02 |
| C-reactive protein (mg/l) | HR 1.01 (95%CI 1.00-1.01) | 0.03 |
| Troponin T (ug/l) | HR 1.06 (95%CI 1.01-1.19) | 0.02 |
| B-type natriuretic peptide (pg/ml) (for every increase of 100 pg/ml) |
HR1.00 (95%CI 0.99-1.02) | 0.80 |
| LV ejection fraction (%) | HR 0.99 (95%CI 0.97-1.02) | 0.53 |
| Creatinine (mmol/l) (for every increase of 10 mml/l) |
HR 1.13 (95%CI 1.01-1.20) | < 0.001 |
| NGAL ng/ml (for every increase of 10 ng/ml) |
HR 1.01 (95%CI 1.04-1.15) | < 0.001 |
| NGAL > 94 ng/ml | HR 1.44 (96%CI 0.15-14.20) | 0.76 |
| NGAL > 140 ng/ml | HR 3.40 (95%CI 1.61-7.15) | 0.001 |
| Multivariate analysis | ||
| Hx Heart Failure | HR 1.75 (95%CI 0.64-4.80) | 0.24 |
| Steady State Creatinine > 110 μmol/l | HR 2.41 (95%CI 0.66-8.88) | 0.41 |
| Systolic Blood Pressure (mmHg) | HR 1.01 (95%CI 0.99-1.02) | 0.43 |
| Outpatient Diuretic Treatment | HR 1.25 (95%CI 0.32-4.02) | 0.58 |
| Loop Diuretic Dose during first 72h | HR 1.00 (95%CI 0.99-1.00) | 0.86 |
| C-reactive protein (mg/l) | HR 1.00 (95%CI 0.99-1.01) | 0.95 |
| Troponin T (ug/l) | HR 3.72 (95%CI 0.02-13.53) | 0.63 |
| Creatinine (mmol/l) (for every increase of 10 mml/l) |
HR 1.12 (95%CI 1.00-1.24) | 0.04 |
| NGAL (ng/ml) (for every increase of 10 ng/ml) |
HR 1.05 (95%CI 0.98-1.13) | 0.18 |
To limit the effects of co-linearity between multiple parameters of renal and cardiac function multivariate analysis contained only the strongest univariate predictor in each class (acute renal function, chronic renal impairment, acute cardiac injury, chronic heart failure).