Table 4.

Renal perfusion and function

		6% HES 130	10% HES 200	RAc	4% gelatin	SHAM
Left renal artery flow, ml/kgBW/min	Baseline	7.0 ± 2.9	7.5 ± 2.9	6.1 ± 2.2	6.8 ± 0.4	8.3 ± 3.7
	Before sepsis	5.3 ± 3.8	6.8 ± 2.6	4.6 ± 1.5	6.4 ± 0.5	8.9 ± 5.0
	12 h after sepsis	9.6 ± 3.7	4.0 ± 3.1	5.0 ± 1.9	6.7 ± 2.0	11.4 ± 8.3
Crea as percentage of baseline, %	Baseline	-	-	-	-	-
	Before sepsis	4 ± 5	12 ± 5 ‡	10 ± 6	14 ± 6 ‡	-2 ± 2
	12 h after sepsis	-13 ± 7	87 ± 84**; +	-4 ± 13	26 ± 13	-4 ± 13
Crea clearance, ml/min	Baseline	136 ± 24	130 ± 87	108 ± 94	101 ± 46	117 ± 13
	Before sepsis	98 ± 47	57 ± 36	57 ± 51	48 ± 17	78 ± 10
	12 h after sepsis	97 ± 15	13 ± 14 *	76 ± 23	38 ± 8 ‡; +	98 ± 48
Urine output, ml/kgBW/h	Baseline	-	-	-	-	-
	Before sepsis	-	-	-	-	-
	12 h after sepsis	3.3 ± 1.3	0.5 ± 0.3	11.5 ± 12.3	1.1 ± 0.2	2.2 ± 1.9
Cl, mmol/l	Baseline	100 ± 1	100 ± 2	99 ± 2	100 ± 2	100 ± 1
	Before sepsis	100 ± 1	103 ± 2	100 ± 1	98 ± 2	101 ± 2
	12 h after sepsis	103 ± 2	111 ± 2	109 ± 9	98 ± 2 **; ║	101 ± 2
Na, mmol/l	Baseline	135 ± 1	135 ± 2	136 ± 2	136 ± 1	136 ± 1
	Before sepsis	136 ± 2	138 ± 2	137 ± 3	138 ± 2	137 ± 1
	12 h after sepsis	136 ± 2	140 ± 3	144 ± 11	138 ± 3	136 ± 2
K+, mmol/l	Baseline	4.5 ± 0.4	4.4 ± 0.3	4.5 ± 0.2	4.4 ± 0.1	4.4 ± 0.2
	Before sepsis	3.7 ± 0.2	3.8 ± 0.3	4.0 ± 0.2	3.9 ± 0.2	4.4 ± 0.1
	12 h after sepsis	3.9 ± 0.5	5.6 ± 1.7	4.0 ± 0.3	4.9 ± 1.1	3.8 ± 0.1
Aniongap mmol/l	Baseline	10.2 ± 0.8	10.0 ± 0.3	9.9 ± 1.9	10.4 ± 0.5	10.4 ± 1.4
	Before sepsis	9.6 ± 0.3	9.2 ± 1.4	9.8 ± 1.3	11.4 ± 1.0	9.4 ± 1.4
	12 h after sepsis	6.8 ± 0.7	10.9 ± 4.2	8.2 ± 1.2	15.4 ± 4.2**;+	9.5 ± 0.2

Data are presented as mean ± SD at baseline, 6 h after hemorrhagic shock and before sepsis induction (before sepsis) and 12 h after sepsis induction.

BW, body weight; Cl, chloride; Crea, creatinine; K⁺ , potassium; Na, sodium.

* P ≤ 0.01 vs. 6% HES130, RAc and SHAM; ** P ≤ 0.05 vs. RAc; + P ≤ 0.05 vs. 6% HES130; ‡ P ≤ 0.05 vs. SHAM; ║ P ≤ 0.05 vs. 10% HES200.