Figure 5.

Simulated volume-time curves for the central (V_c) and peripheral (V_t) fluid spaces and urinary excretion. Thin lines are simulations based on k₁₂, k₂₁, and k₁₀ from each operation, and thick lines are the median for each group. The points in the lower panel are the measured urinary excretion (median values). k₁₀, rate constant for fluid leaving the system; k₁₂, rate constant for fluid passing from v_c to v_t; k₂₁, rate constant for fluid passing from v_t to v_c; v_c, size of central body fluid space during fluid therapy; V_c, size of central body fluid space at baseline; v_t, size of peripheral body fluid space during fluid therapy; V_t, size of peripheral body fluid space at baseline.