Table 4.
Detailed calculations of the urinary excretion
| Measured parameters | Controls (n = 20) |
Esmolol (n = 20) |
Phenylephrine (n = 20) |
Kruskal- Wallis test |
|---|---|---|---|---|
| Infused volume, mL | 1,000 (950-1,100) | 1,060 (985-1,180) | 1,090 (970-1,190) | NS |
| Cumulative urine volume, mL | ||||
| 40 minutes | 13 (3-38) | 26 (8-58) | 54 (25-91) | NS |
| 60 minutes | 36 (15-99) | 71 (43-150) | 135 (58-195) | P < 0.05 |
| 120 minutes | 81 (45-200) | 194 (119-352) | 236 (97-353) | P < 0.01 |
| 180 minutes | 93 (53-226) | 237 (136-416) | 276 (168-375) | P < 0.01 |
| Non-surgery | 43 (27-142) | 147 (73-228) | 176 (88-285) | P < 0.03 |
| Surgery | 34 (24-53) | 65 (46-122) | 61 (39-129) | P < 0.04 |
| Urine flow, mL/minute | ||||
| 0-180 minutes | 0.51 (0.29-1.22) | 1.30 (0.76-2.31) | 1.53 (0.93-2.05) | P < 0.01 |
| Non-surgery | 0.50 (0.25-1.18) | 1.33 (0.95-2.63) | 1.72 (0.86-2.70) | P < 0.01 |
| Surgery | 0.51 (0.33-0.83) | 0.77 (0.54-1.51) | 0.80 (0.54-1.34) | NSa |
| Excreted/infused at 180 minutes, percentage | 8.8 (4.9-20.2) | 20.4 (13.8-38.0) | 25.4 (14.9-36.4) | P < 0.01 |
Data are the median (25th to 75th percentiles). aP = 0.11; esmolol versus controls P < 0.05 (Mann-Whitney test). NS, not significant.