Table 5.

Proposed diagnostic criteria of kidney dysfunction in cirrhosis [47]

Diagnosis	Definition
Acute Kidney Injury	• A rise in Scr ≥ 50% from baseline, or a rise Scr > 0.3 mg/dL • Type-1 HRS is a specific form of acute kidney injury
Chronic Kidney Disease	• GFR < 60 ml/min for > 3 month calculated using MDRD-6 formula
Acute on Chronic Kidney Disease	• Rise in Scr ≥ 50% from baseline or a rise of Scr > 0.3 mg/dL in a patient with cirrhosis whose GFR is < 60 ml/min for > 3 month calculated using MDRD-6 formula

GFR, glomerular filtration rate; HRS, hepatorenal syndrome; Scr, serum creatinine. Both the acute deterioration in renal function and the background chronic renal dysfunction can be functional or structural in nature. MDRD-6: GFR = 170 × Scr (mg/dL)^-0.999 x age^-0.176 x 1.180 (if black) × 0.762 (if female) × serum urea nitrogen^-0.170 × albumin^0.138