Table 7.
Extracorporeal liver support system
| Technique | |
|---|---|
| Artificial (Non-cell based) | |
| Hemoperfusion [96-101] | Removal of protein-bound toxins by circulating blood over a sorbent material |
| Hemodiabsorption [102-105] | Hybrid process in which blood is passed through a hemodialyzer containing a suspension of sorbent material, such as charcoal or resin, in the extracapillary space |
| Plasma Exchange [106-109] | Exchange of plasma volume |
| Plasmapheresis [110] | Plasma is separated from the cellular blood components and replaced with normal plasma constituents, allowing the removal of circulating toxins and waste products. |
| Plasma Filtration [111-117] | Removes a specific plasma fraction containing substances within a specific molecular weight. |
| Albumin dialysis | Albumin containing dialysate using an anion exchange resin and active charcoal adsorption allowing albumin-bound toxins in the blood to cross the membrane and bind to the albumin. Water soluble toxins are dialyzed from the albumin circuit by a standard hemodialysis or continuous renal replacement therapy (CRRT) machine. |
| • Single Pass Albumin Dialysis (SPAD) 118-121] | |
| • Prometheus [122-124] | |
| • Molecular Adsorbent Recirculating System (MARS) [125-131] | |
| Bioartificial (Cell-based) [132-134] | |
| Porcine | |
| • HepatAssist • Bioartificial Liver Support System (BLSS) • Modular Extracorporeal Liver Support (MELS) • Hybrid-Bioartificial Liver (HBAL) • Radial Flow Bioreactor (RFB) • TECA-Hybrid Artificial Liver Support System • AMC-Bioartificial Liver |
|
| Human | |
| • Extracorporeal Liver Assist Device (ELAD) |