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. 2012 Jun 15;6:116–122. doi: 10.2174/1874312901206010116

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© Tourkina and Hoffman; Licensee Bentham Open.

This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

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Fig. (2) — The Caveolin-1/CXCR4/CXCL12 Axis in Fibrosis. Profibrotic signals induce the differentiation in the bone marrow of a population of CD45+/CXCR4+/ColI+/caveolin-1 low cells that can be either CD14+ (filled circles) or CD14- (open circles). Under the influence of CXCL12, these cells traffic into the blood, then into damaged lung tissue where they begin to lose CD45 and to differentiate into myofibroblasts. CD45+/CXCR4+/ColI+/CD14- cells are fibrocytes, CD45+/CXCR4+/ColI+/CD14+ cells are referred to as collagen-producing monocytes [70].