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. 2012 Jul;22(7):1197–1211. doi: 10.1101/gr.132662.111

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© 2012, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 4. — Identification of DNA methylation differences between lung adenocarcinoma tumors and NTL with regard to smoking. (A) Correlation matrix of median β-values of tumors from current smokers vs. never-smokers, with the Spearman rho correlation given in the top left corner. (B) Volcano plot of the differential DNA methylation analysis between tumors from smokers and never-smokers. (Vertical dotted lines) 20% change in β-values; (horizontal dotted line) the significance cutoff. (C) Correlation plot of DNA methylation vs. expression for LGALS4. The Spearman rho correlation coefficient is provided on top. (D) Correlation matrix of median β-values of NTL from current smokers vs. never-smokers, with the Spearman rho correlation given in the top left corner. (E) Volcano plot of the differential DNA methylation analysis between NTL from smokers and never-smokers. (Vertical dotted lines) 20% change in β-values; (horizontal dotted line) the significance cutoff. No significant DNA methylation differences are seen between NTL from smokers and never-smokers.