Table S4.

Results for the curve fitting parameters of different model functions for 5-fluorouracil release profiles

Model function	% 5-FU loading	Release rate constant (K, day−1)	Regression coefficient (R2)	Release index (n)	Probability (P)
Lonsdale model	9% 5-FU	0.01 ± 0.002	0.01	–	0.003
Peppas model	9% 5-FU	40.43 ± 0.47	0.97	0.075 ± 0.005	<0.001
Hixson model	9% 5-FU	0.02 ± 0.004	0.03	–	<0.001
Higuchi model	9% 5-FU	16.82 ± 1.71	0.01	–	<0.001
First order model	9% 5-FU	0.08 ± 0.02	0.02	–	<0.001
Lonsdale model	9.5% 5-FU	0.004 ± 0.0001	0.79	–	<0.001
Peppas model	9.5% 5-FU	35.29 ± 0.39	0.92	0.069 ± 0.002	<0.001
Hixson model	9.5% 5-FU	0.02 ± 0.003	0.03	–	<0.001
Higuchi model	9.5% 5-FU	14.67 ± 1.42	0.09	–	<0.001
First order model	9.5% 5-FU	0.06 ± 0.01	0.02	–	<0.001
Lonsdale model	10% 5-FU	0.04 ± 0.01	0.01	–	0.004
Peppas model	10% 5-FU	32.76 ± 0.32	0.98	0.071 ± 0.004	<0.001
Hixson model	10% 5-FU	0.02 ± 0.002	0.03	–	<0.001
Higuchi model	10% 5-FU	13.48 ± 1.41	0.01	–	<0.001
First order model	10% 5-FU	0.06 ± 0.01	0.02	–	<0.001

Abbreviation: 5-FU, 5-Fluorouracil.