Table S1.

Mathematical models describing release rates of 5-fluorouracil and progesterone from the hollow nanoaggregates^14–16

Model	Equation
Zero order	$C=K_{0}t$
First order	$Log\hspace{0.17em}C=Log\hspace{0.17em}{C}_0-Kt/2.303$
Hixson-Crowell	$Q_0^{1/3}-Q_t^{1/3}=Kt$
Higuchi	$Q={Kt}^{0.5}$
Peppas	$Q={kt}^n$
Modified Peppas	$Q={at}^n+b$
Weibull	$Q=1-\text{exp}(-a{t}^b)$
Lonsdale and Baker	$\frac{2}{3}\left(1-{\left\{1-\frac{Q}{100}\right\}}^{\frac{2}{3}}\right)-\left\{\frac{Q}{100}\right\}=Kt$

Notes: where C is the concentration of drug released, C₀ is the initial concentration of drug, K is the release rate constant in units of concentration/time, Q is the amount of drug released in time t, Q₀ is the initial amount of drug loaded into the nanoaggregates, and the release index is symbolized as n.