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. Author manuscript; available in PMC: 2012 Jul 13.
Published in final edited form as: Amyloid. 2011 Jun 13;18(3):98–107. doi: 10.3109/13506129.2011.580399

Table 1.

Critical concentration and ΔG0 of fibril formation.

Peptides Cr (μM) p-value ⊗G0 (kcal/mole) p-value
Aβ40 1.24 ± 0.09 <0.001 -8.38 ± 0.04 <0.001
[ΔE22]Aβ40 0.58 ± 0.07 -8.85 ± 0.07
Aβ42 0.87 ± 0.05 <0.001 -8.59 ± 0.03 =0.003
[ΔE22]Aβ42 0.32 ± 0.09 -9.23 ± 0.16

Aβ40 and [ΔE22]Aβ40, both at concentrations of 20 μM, and Aβ42 and [ΔE22]Aβ42, both at concentrations of 10 μM, were incubated in 10 mM phosphate buffer, pH 7.4, at 37°C for ≈3 weeks. Critical concentration, Cr, is the molar concentration of peptide in the supernate after high-speed centrifugation (436,000 × g for 1 h) after cessation of fibril growth. ΔG0 = –RT ln (1/Cr). The values shown are average concentration ± S.D. p-values for the significance of the differences between each pair of Cr values or ΔG0 values are shown to the right of the respective two values. The results comprise four independent experiments.