. Author manuscript; available in PMC: 2013 Jun 4.

Published in final edited form as: Mol Pharm. 2012 May 21;9(6):1775–1784. doi: 10.1021/mp3000716

Table 3.

Enrichment factor EF_0.01 of different methods for functional relationship detection for the 168 testing human GPCRs.

Method	Sequence cutoff 30%	Exclude target only	No cutoff
fr-TM-align with evolutionary score	22.7	41.4	64.2
BLAST	18.9	39.9	63.9
PSI-BLAST (5 iterations)	16.3	28.5	50.2
HHSEARCH	13.1	33.2	64.2
fr-TM-align	13.3	22.3	64.2