Table 1.

Effect of lithium–pilocarpine induced seizures on local cerebral glucose utilization in rats

Brain structure	Control (n = 4)	Seizures (n = 6)	Variation (%)
Cerebral cortex
Frontal cortex	71.0 ± 7.8	375.9 ± 32.4***	+429
Cingulate cortex	75.7 ± 5.3	330.9 ± 23.0****	+337
Olfactory cortex	69.1 ± 6.0	288.0 ± 24.8****	+317
Piriform cortex	47.5 ± 3.1	288.3 ± 26.6****	+507
Limbic structures
Nucleus accumbens	47.7 ± 5.0	226.6 ± 49.8***	+376
Amygdala	33.2 ± 3.3	226.9 ± 34.6***	+582
Hippocampus, CA1	51.9 ± 6.6	103.3 ± 8.7**	+98
Hippocampus, CA3	68.3 ± 4.4	243.6 ± 18.4****	+257
Dentate gyrus	40.2 ± 3.3	223.2 ± 23.7***	+455
Striatum and related areas
Caudate nucleus	66.6 ± 5.9	319.1 ± 43.3***	+379
Substantia nigra pars reticulata	40.0 ± 2.7	167.2 ± 30.6***	+318
Hypothalamus
Anterior	40.1 ± 5.7	118.7 ± 15.5***	+196
Ventromedian	41.9 ± 3.6	126.7 ± 23.4***	+203
Thalamus
Ventrolateral	78.7 ± 6.6	233.7 ± 38.4****	+197
Mediodorsal	80.7 ± 5.5	374.5 ± 30.1****	+364
Medial geniculate body	86.3 ± 9.8	231.0 ± 41.3***	+168
Brainstem
Inferior colliculus	138.9 ± 24.3	113.8 ± 18.8	−19
Cerebellar cortex	43.6 ± 5.1	76.0 ± 15.3*	+74

Values are means ± S.D. of the number of animals in parentheses.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001,

^****p < 0.0001, statistically significant differences from controls (Student’s t-test).