TABLE 2.
HRs (95% CIs) for the association of plasma phospholipid α-linolenic acid with incident congestive heart failure and nonvalvular congestive heart failure in 2957 participants in the Cardiovascular Health Study1
| Quartile of plasma phospholipid α-linolenic acid |
|||||
| 1 | 2 | 3 | 4 | P-trend | |
| Total congestive heart failure | |||||
| Person-years | 7838 | 7570 | 7469 | 7846 | |
| No. of incident cases | 191 | 169 | 161 | 165 | |
| Model 1 | Reference | 0.95 (0.77, 1.17) | 0.91 (0.74, 1.13) | 0.88 (0.72, 1.09) | 0.23 |
| Model 2 | Reference | 0.97 (0.78, 1.20) | 0.98 (0.79, 1.22) | 0.97 (0.79, 1.21) | 0.85 |
| Nonvalvular congestive heart failure | |||||
| Person-years | 7838 | 7570 | 7469 | 7846 | |
| No. of incident cases | 123 | 109 | 92 | 107 | |
| Model 1 | Reference | 0.93 (0.72, 1.21) | 0.80 (0.61, 1.05) | 0.88 (0.68, 1.15) | 0.22 |
| Model 2 | Reference | 0.98 (0.75, 1.28) | 0.88 (0.67, 1.16) | 1.03 (0.79, 1.34) | 0.95 |
HRs and 95% CIs were calculated by using multivariate Cox proportional hazard regression. Model 1 was adjusted for age (y) and sex. Model 2 was adjusted as for model 1 with additional adjustment for enrollment site (4 sites), race (white, nonwhite), education (<high school, high school, college), smoking (never, former, current), leisure-time physical activity (kcal/wk), BMI (kg/m2), waist circumference (cm), and alcohol consumption (g/d).