TABLE 4.

Safety assessment scale

SCALING
SCORE	GRADE	DESCRIPTION
0	None	No scaling
1	Mild	Barely perceptible, fine scales present to limited areas of the face
2	Moderate	Fine scale generalized to all areas of the face
3	Severe	Scaling and peeling of skin over all areas of the face
ERYTHEMA
SCORE	GRADE	DESCRIPTION
0	None	No evidence of erythema present
1	Mild	Slight pink discoloration
2	Moderate	Definite redness
3	Severe	Marked erythema, bright red to dusky dark red in color
ITCHING
SCORE	GRADE	DESCRIPTION
0	None	No itching
1	Mild	Slight itching, not really bothersome
2	Moderate	Definite itching that is somewhat bothersome
3	Severe	Intense itching that may interrupt daily activities and/or sleep
BURNING
SCORE	GRADE	DESCRIPTION
0	None	No burning
1	Mild	Slight burning sensation, not really bothersome
2	Moderate	Definite warm, burning sensation that is somewhat bothersome
3	Severe	Hot burning sensation that causes definite discomfort and may interrupt daily activities and/or sleep
STINGING
SCORE	GRADE	DESCRIPTION
0	None	No stinging
1	Mild	Slight stinging sensation, not really bothersome
2	Moderate	Definite stinging sensation that is somewhat bothersome
3	Severe	Stinging sensation that causes definite discomfort and may interrupt daily activities and/or sleep

From: Leyden J, Wortzman M, Baldwin EK. Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel. J Drugs Dermatol. 2009;8:383-388.13