Fig. 5.

Deletion of p38γ and p38δ decreases LPS/d-Gal–induced lethality. (A–C) Mice received injections of LPS (50 μg/kg) and d-Gal (1 g/kg), and death was monitored for up to 36 h. Wild type (n = 14) and (A) p38γ^−/− (n = 15), (B) p38δ^−/− (n = 11), or (C) p38γ/δ^−/− (n = 12) are shown. (D) Serum from mice in A–C was collected 2 h after LPS and d-Gal challenge, and TNFα and IL-1β were measured in a luminex cytokine assay. Data show mean ± SD (n = 4–6 mice/group). *P ≤ 0.05 and **P ≤ 0.01 relative to WT mouse serum.