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. 2012 Jun 18;109(28):E1938–E1946. doi: 10.1073/pnas.1206999109

Fig. 4.

Fig. 4.

Regional neuropathology of infected mice. (A–D) Profiles of vacuolation scores of animals inoculated with samples containing (A) input prions, (B) cofactor PrPSc molecules, (C) PE PrPSc prions, or (D) serial-passage PE PrPSc prions. (E–H) Profiles of PrP deposition scores of animals inoculated with samples containing (E) input prions, (F) cofactor PrPSc molecules, (G) PE PrPSc prions, or (H) serial-passage PE PrPSc prions. Prion strains: OSU, red squares; Me7, blue circles; 301C, green triangles. Brain regions: I–II, cerebral cortical layers 1 and 2; III–IV, cortical layers 3 and 4; V–VI, cortical layers 5 and 6; BS, brainstem; Cb, cerebellum; CC, cerebral cortex (all layers); H, hippocampus; HT, hypothalamus; Mid, midbrain; T, thalamus. Mean values ± SEM are shown; n = 5.