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Ca2+ signaling may be a common mechanism for NLRP3 inflammasome activation. (A and B) LPS-primed BMDMs stimulated with nigericin (A) or MSU (B) were analyzed by Ca2+ imaging. In B, buffer exchange to remove (0 Ca2+) and replace Ca2+ (1 mM Ca2+) indicates contribution of store-operated Ca2+ entry to Ca2+ flux. (C–F) BMDMs stimulated as indicated were examined for NLRP3 inflammasome activation.
