Fig. 2.

Cholinergic neurons mediate the effects of p11 on depression-like behaviors. (A) ChAT-, D2-, A2a-, and D1- p11 KO mice were tested for sucrose preference, a model for the hallmark depressive symptom of anhedonia [F_(4,107) = 2.578, P < 0.05]. (B) Baseline immobility and the response to citalopram, an SSRI antidepressant, were measured in the tail suspension test in ChAT-, D2-, A2a-, or D1-p11 KO mice [genotype: F_(4,111) = 8.604, P < 0.01; citalopram: F_(1,111) = 64.5, P < 0.01; interaction: F_(4,111) = 0.3805, n.s.]. All data are presented as means ± SEM. Statistically significant effects of genotype (*P < 0.05) or citalopram (#P < 0.05) are noted. n.s., not significant.