Table 2.
Distribution of subject scores according to clinical prediction rules, population-based cohort
| Total | No mutation | With mutation | |||||
|---|---|---|---|---|---|---|---|
| Characteristics | N | (%) | N | (%) | N | (%) | P value |
| PREM1,2,6 | |||||||
| <5% | 30 | (5) | 29 | (5) | 1 | (7) | |
| 5–9% | 443 | (79) | 439 | (80) | 4 | (29) | |
| 10–19% | 63 | (11) | 59 | (11) | 4 | (29) | |
| 20–29% | 13 | (2) | 12 | (2) | 1 | (7) | |
| 30–39% | 6 | (1) | 5 | (1) | 1 | (7) | |
| ≥40% | 8 | (2) | 5 | (1) | 3 | (21) | |
| Total | 563 | (100) | 549 | (100) | 14 | (100) | |
| Mean score (±SD) | 8 | (±8) | 8 | (±7) | 23 | (±24) | 0.03 |
| MMRpredict (proximal) | |||||||
| <0.5% | 0 | (0) | 0 | (0) | 0 | (0) | |
| 0.5–4% | 97 | (62) | 95 | (64) | 2 | (29) | |
| 5–19% | 38 | (24) | 37 | (25) | 1 | (14) | |
| 20–44% | 6 | (4) | 6 | (4) | 0 | (0) | |
| ≥45% | 15 | (10) | 11 | (7) | 4 | (57) | |
| Total | 156 | (100) | 149 | (100) | 7 | (100) | |
| MMRpredict (distal) | |||||||
| <0.5% | 61 | (39) | 60 | (40) | 1 | (14) | |
| 0.5–4% | 73 | (47) | 71 | (48) | 2 | (29) | |
| 5–19% | 11 | (7) | 10 | (7) | 1 | (14) | |
| 20–44% | 7 | (4) | 5 | (3) | 2 | (29) | |
| ≥45% | 4 | (3) | 3 | (2) | 1 | (14) | |
| Total | 156 | (100) | 149 | 100 | 7 | (100) | |
| Mean score (±SD) – proximal | 11 | (±20) | 10 | ±18 | 42 | ±39 | 0.08 |
| Mean score (±SD) – distal | 5 | (±12) | 4 | ±10 | 26 | ±35 | 0.14 |
| MMRpro | |||||||
| <5% | 191 | (82) | 185 | (85) | 6 | (43) | |
| 5–9% | 18 | (8) | 16 | (7) | 2 | (14) | |
| 10–19% | 8 | (3) | 7 | (3) | 1 | (7) | |
| 20–29% | 4 | (2) | 4 | (2) | 0 | (0) | |
| 30–39% | 1 | (1) | 1 | (1) | 0 | (0) | |
| ≥40% | 10 | (4) | 5 | (2) | 5 | (36) | |
| Total | 232 | (100) | 218 | (100) | 14 | (100) | |
| Mean score (±SD) | 6 | (±18) | 4 | (±13) | 34 | (±44) | 0.02 |