Figure 7. In silico promoter analysis of Oat1, Oat3, and Oct1 transporters predicts regulation by HNF4α.

Diagram of the promoters of the human, rat, and mouse Oct1, Oat1 and Oat3 promoters. Under stringent settings only a single TRANSFAC binding motif remained - V$NR2F. Six transcripts had a DR-1 binding element within the proximal promoter region, and one had a DR-2 binding element, resulting in 7 of 9 transcripts predicted to have the potential to recruit Hnf4α directly. Green markers depict binding sites for members of the Nuclear Receptor 2 family as a function of position relevant to known transcription start sites. DR-1 elements are circled, the single DR-2 element is marked by a square. Yellow shading denotes a direct call of HNF4α by Genomatix.