Table 1. Literature based “legacy” genes provide a core to build a SS to PT development network.

Gene (Node)	Source
Notch 1, 2	[17], [21]
RBPJ	[21]
Hyaluronic Acid	[26]
CD44 (HA receptor)	[26]
RHAMM (HMMR, HA receptor)	[26]
E-Cadherin (CDH1)	[27]
ZO-1 (TJP1)	[27]
Lim1 (LHX1)	[29]
Brn1 (POU3F3)*	[30]
Oat1 (SLC22A6)	[12]
Oat3 (SLC22A8)	[12]
Oct1 (SLC22A1)	[12]
Oct2 (SLC 22A2)	[13]
(SLC 47A1)	[13]
(SLC 15A2)	[13]
WT1	[28]
Jag1	[17]
Dll1	[17]
Hey1	[22]
Hes1	[22], [23]
Hnf1a	[24]
Hnf4a	[25]

Genes representing known regulators of nephron development and of proximal tubule function were used as the basis of the s-shaped body to proximal tubule stage specific network. This core of genes is the basis for addition of differentially expressed genes from in vitro and in vivo microarray experiments.

^*Brn1 is determinant of distal tubular development.