Figure 3. Effect of iontophoresis of bosentan 10.

⁻² M, sitaxentan 10 ⁻² M and NaCl 0.9% on skin blood flux during infusion of i.a. endothelin 0.5 10 ⁻⁵ M in rats, expressed as arbitrary perfusion units mean (mean±SEM), in the cathodal direction ( Fig 3A ) and anodal direction (Fig. 3B).