Table 1. IgM linked SerpinB3 and SerpinB4 isoforms, compared to total SCCA-IgM in patients with different extent of chronic liver disease.
Chronic hepatitis | Cirrhosis | HCC | Healthy Subjects | ||
n = 17 | n = 36 | n = 26 | n = 28 | ||
SerpinB3-IgM (SCC111) | Median (OD405 nm) | 0.130 | 0.130 | 0.130 | 0.130 |
IQR | 0.130–0.172 | 0.130–0.221 | 0.130–0.175 | 0.130–0.130 | |
95th percentile | 0.200 | ||||
% positivity | 12 | 28 | 23 | 7 | |
SerpinB4-IgM (SCC103) | Median (OD405 nm) | 0.207 | 0.168 | 0.140 | 0.154 |
IQR | 0.140–0.275 | 0.140–0.427 | 0.140–0.278 | 0.140–0.249 | |
95th percentile | 0.384 | ||||
% positivity | 12 | 28 | 23 | 7 | |
SerpinB4-IgM (SCC104) | Median (OD405 nm) | 0.126 | 0.135 | 0.125 | 0.125 |
IQR | 0.125–0.227 | 0.125–0.285 | 0.125–0.319 | 0.125–0.125 | |
95th percentile | 0.199 | ||||
% positivity | 29 | 42 | 35 | 7 | |
Total SCCA-IgM | Median (AU/mL) | 166 | 134 | 209 | 115 |
IQR | 80–511 | 80–552 | 118–287 | 109–129 | |
95th percentile | 156 | ||||
% positivity | 53 | 47 | 58 | 0 |
IQR = interquartile range (25th–75th percentile).
The percentage of positivity for each immunocomplex was determined as the fraction number of patients with immunocomplex levels above the defined cut-off value (95th percentile).