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. 2012 Jul 13;7(7):e40794. doi: 10.1371/journal.pone.0040794

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Orlando et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Histological analysis of human breast tumors formed 70 days after injection of 5×10⁶ MCF-7 Tet-Off/ACSL4 cells into the right flank of female Balb/c nu/nu mice, aged 6–8 weeks. Panel A, C and D showed a representative hematoxylin & eosin stained tissue sections of MCF-7 Tet-Off/ACSL4, MCF-7 Tet-Off empty vector, and MCF-7 Tet-Off/ACSL4 plus doxycyclin treated tumors respectively. Panel B showed a representative immunohistochemical analysis of Ki-67 stained of MCF-7 Tet-Off/ACSL4 tumors. Tumor specimens were stained for detection of ERα and PR receptor expression using the specific antibodies as described in Materials and Methods. Panels showed a representative inmunohistochemical analysis of ERα and PR of the tumor from MCF-7 Tet-Off/ACSL4 xenografts (panel 3E and 3F respectively); from MCF-7 Tet-Off empty vector (panel 3G and 3H respectively) and from MCF-7 Tet-Off/ACSL4 xenografts treted with doxycycline (panel 3I and 3J respectively.