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. 2012 Jul 13;7(7):e40754. doi: 10.1371/journal.pone.0040754

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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mRNA expression of differentiation gene loricrin (LOR), filaggrin (FLG), keratin 5 (K5) and keratin 10 (K10) in the tumor center (T), tumor margin (M), peritumoral tissue (P) and distant normal skin (N) in cutaneous squamous cell carcinoma (SCC, black bars) and basal cell carcinoma (BCC, white bars). Relative mRNA expression to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and normalized to normal skin is shown. Depicted are mean ± SEM values. *p<0.05, **p<0.01, ***p<0.001 by Kruskal-Wallis test with Dunn’s post-test for comparison between N, P, M and T and by Mann Whitney U test for comparison between SCC and BCC in each group. N = 28 SCC and 19 BCC.