Table 2. Final characteristics of High Fat-Diet (HFD) fed mice and Zucker fa/fa rats (control and AAV5 Ex-4 treated animals).
| Control HFDmice | AAV5 Ex-4HFD mice | p* | Control Zuckerfa/fa rats | AAV5 Ex-4 Zuckerfa/fa rats | p* | |
| n | 10 | 10 | 5 | 5 | ||
| Weight gain (g) | 19.5±1.9 | 16.5±2.7 | p<0.01 | 241.4±22.5 | 222±23.4 | p<0.05 |
| Fasting glycemia (mmol/L) | 4.9±0.9 | 4.8±0.7 | p>0.05 | 5.7±0.4 | 5.6±0.5 | p>0.05 |
| Insulinemia (pmol/L) | 150.6±6.1 | 126.3±4.0 | p<0.01 | 3862.9±320.3 | 3164.8±265.0 | p<0.05 |
| HOMA-IR index (units) | 5.5±0.4 | 4.5±0.4 | p>0.05 | 163.1±15.0 | 131.2±11.2 | p<0.05 |
| HbA1c (%) | 4.2±0.2 | 4.1±0.2 | p>0.05 | 5.0±0.1 | 4.7±0.1 | p<0.05 |
| Glycosuria (number positive) | 0 | 0 | 4 | 0 | p<0.05 | |
| Daily food intake (g) | 4.3±0.3 | 4.6±0.3 | p>0.05 | 21.2±2.1 | 21.3±1.9 | p>0.05 |
*
Control in comparison to AAV5 Ex-4 HFD mice and control versus AAV5 Ex-4 Zucker fa/fa rats, respectively.