Figure 6. Conserved co-regulatory network in both Homo sapiens and Mus musculus species.

Each interconnected edge (representing a pair of modifier/regulator) must satisfy three criteria, i.e., existed in both human and mouse, the Bonforroni adjusted p<0.001 and the intersection genes of the pair was enriched at least 2-fold. The gene symbols are shown as in Mus musculus species. The node size is in proportion to its degree and color represents different types of modifier/regulator, red, DNA hydroxy/methylation; blue, hisotone modification and yellow, transcription factor.