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. 2012 Jul 13;7(7):e40943. doi: 10.1371/journal.pone.0040943

Figure 2. HOXB13 expression was regulated by DNA methylation.

Figure 2

BSP assays showed the methylation of CpG islands at the HOXB13 promoter in highly malignant DU145 cells (A) and in lowly malignant LNCap cells (B). (C) HOXB13 was upregulated in DU145 cells transfected with the DNMT3b siRNA plasmid, compared with the cells transfected with control siRNA vector. (D) BSP assays showed the reduced methylation level of HOXB13 promoter in DU145 cells transfected with DNMT3b siRNA (lower), compared with control siRNA (upper).