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. 2012 Jul 13;7(7):e38530. doi: 10.1371/journal.pone.0038530

Figure 4. EPO/EPOR – modulation of cytokines plus receptors, and negative feedback factors.

Figure 4

A] Cytokines/ receptors modulated due to EPOR ligation included Tnfr-sf13c (BAFF receptor), Cmtm6 (transmembrane chemokine receptor like superfamily-6), Lrp8 (cholesterol co-receptor), Gdf3 (a BMP antagonist), and Oncostatin-M (a new indirect mediator of iron transport). B] Among negative-feedback factors, EPOR ligation up modulated five prime factors as Spred2, Spred1, Edf1, Socs2, and Socs3. C] For Tnfr-sf13c, associated factors and pathways are outlined (based on Ingenuity algorithms). D] For Spred-1 and -2, associated factors and pathways are outlined.