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. 2012 Jul 13;7(7):e39392. doi: 10.1371/journal.pone.0039392

Figure 1. Peak inspiratory pressure (PIP), tidal volume (VT), and pCO2.

Figure 1

Preterm newborn lambs were resuscitated after birth with (A) high peak inspiratory pressure (PIP) to regulate (C) tidal volume (VT) at 6 ml/kg. CHF5633, Survanta, or Air was given at 15 min of age and ventilation was changed to regulate (B) Pco2 at 50–60 mmHg. Lung immaturity was comparable between the groups and all the control (Air) lambs died within 90 min of age. PIP and Pco2 were similarly improved by treatment with CHF5633 and Survanta. Initial response of VT to surfactant treatment was faster by CHF5633 than Survanta. *p<0.03. Some error bars are within symbols.