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. 2012 Jul 13;7(7):e40479. doi: 10.1371/journal.pone.0040479

Figure 1. Frequency of DNA methylation in the investigated ACE promoter region.

Figure 1

(a) Frequency of DNA methylation at 24 CpG sites, located in the (−456/−255) region of the ACE gene in depressive patients (MD) and healthy controls (CON); *: p<0.05 (χ2-test). (b) Sequence of the (−456/−255) region (italic, underlined) including the 24 investigated CpG sites (bold). (c) Frequency of methylation and non-methylation at the 24 CpG sites, located in the (−456/−255) region of the ACE gene in depressive patients (MD) and healthy controls (CON). Patients have a significantly higher methylation status than the healthy controls (p = 0.008, χ2 = 7.1, df = 1). *: p<0.05 (χ2-test).