Figure 3. Possible Impact of Microglia on Personality and Social Behaviors.

Early-life environmental experiences such as psychological stress and traumatic events may activate human microglia, establish a certain neuro-synaptic-microglial connection, which is memorized unconsciously as a primer for an extended period, and this formation in the human brain determines each human’s personality and personality- oriented social behaviors in later life. In sum, neuronal networks with active microglia may induce noisy-decision-making, which is equivalent to personality- oriented behaviors (A). On the other hand, decision-making with neuronal dominant networks may induce straightforward behaviors, which are less affected by personality (B). In the present study, the control group’s personality- oriented behaviors could be formulated by microglial priming effects (A), and the minocycline group’s situation- oriented behaviors may be induced by suppressing microglial contribution to social behaviors (B).