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. 2012 Jul;97(7):980–988. doi: 10.3324/haematol.2011.052522

Figure 2.

Figure 2.

Gelsolin null BALB/c mice show defects in embryonic red blood cells. (A-H) Hematoxylin/eosin staining of blood from wt (A, C, E) and Gsn−/− (B, D, F, G, H) mice embryos showed no gross differences at E13.5 of gestation (panel A-B) and at E.14.5 of gestation (C-D). Some smaller nucleated cells, resembling immature definitive erythroid cells are present (blue arrows, D). At E17.5 of gestation (E-F) mutant (but not wild type) embryos showed a consistent number (about 2.5%) of nucleated definitive erythroid cells in the circulation, together with some primitive nucleated erythroid cells still present in both blood and fetal liver sections (black arrows, G-H). Bars: 24 μm (A-F); 12 μm (G, H).