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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Acta Paediatr. 2012 May 28;101(8):835–845. doi: 10.1111/j.1651-2227.2012.02699.x

Figure 1.

Figure 1

NaCl reabsorption in thick ascending limb and mechanism of diuretic action of Na+-K+-2Cl symport(cotransporter) inhibitors. Numbers in parentheses indicate stoichiometry. Designated voltages are the potential differences across the indicated membrane or cell. The mechanisms illustrated here apply to the medullary, cortical, and postmacular segments of the thick ascending limb. S, symporter; CH, ion channel; BL, basolateral membrane; LM, luminal membrane. From Brunton LL, Chabner BA, Knollmann GC: Goodman & Gilman’s The Pharmacological basis of Therapeutics, 12 Edition: www.accessmedicine.com. With permission.