Figure 2A. Changes of urinary excretion of prostaglandin E in five sick low-birth-weight infants before (C) and after (F) the administration of furosemide, and in two sick low-birth-weight infants before (C) and after (I) administration of indomethacin. From Friedman Z, Demers LM, Marks KH, Uhrmann S, Maisels MJ. J Pediatr 1978;93:512–5. With permission.
Figure 2B. Rates of urinary prostaglandin excretion (PGE) in furosemide-treated (solid circles) and chlorothiazide-treated (open circles) subjects. Asterisks denote p<0.01 compared with the control value. From Green TP, Thompson TR, Johnson DE, Lock JE. N Engl J Med 1983;308:743–8. With permission