Figure 3. Relative cytoadherence of P. falciparum-infected red blood cells to microvascular endothelial cells.
Freshly-drawn red blood cells (RBCs) containing the indicated hemoglobin (Hb) variant were inoculated with laboratory-adapted P. falciparum clones or P. falciparum isolates from Malian children with malaria. After one cycle of invasion and development to the trophozoite stage expressing PfEMP1 and knobs, the cytoadherence of these samples was compared to parasitized HbAA samples processed in parallel. In each experiment, the cytoadherence of HbAA samples is normalized to 100%. These summary data are derived from experiments conducted in [30, 31, 54, 58].