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Phosphatidylinositol-3,4,5-triphosphate (PIP3) is derived from phosphorylation of phosphatidylinositol-4,5-biphosphate (PIP2) by phosphatidylinositol 3-kinases (PI3Ks) in a reversible manner regulated by PTEN. PIP3 activates Akt/protein kinase B (pAkt) that in turn modulates a number of proliferative and anti-apoptotic intracellular processes.
