TABLE 2.
CYP2C19 Genotype Frequencies
| Observed (expecteda) frequency (%) |
|||||
|---|---|---|---|---|---|
| Predicted CYP2C19 metabolizer phenotype/genotype | African-American (n = 250) | Asian (n = 250) | Caucasian (n = 250) | Hispanic(n = 250) | Ashkenazi Jewishb (n = 250) |
| Ultrarapid Metabolizer (UM) | |||||
| *17/*17 | 2.8 (3.3) | 1.6 (0.4) | 2.8 (2.5) | 2.4 (2.3) | 3.6 (3.9) |
| Extensive Metabolizer (EM) | |||||
| *1/*1 | 38.4 (35.3) | 36.4 (37.7) | 49.2 (48.4) | 50.4 (49.6) | 41.6 (39.9) |
| *1/*17c | 20.4 (21.6) | 5.6 (7.6) | 22.8 (22.0) | 20.4 (21.4) | 25.2 (25.0) |
|
|
|||||
| TOTAL: | 58.8 (56.9) | 42.0 (45.3) | 72.0 (70.4) | 70.8 (71.0) | 66.8 (65.0) |
| Intermediate Metabolizer (IM) | |||||
| *1/*2 | 18.4 (23.0) | 37.2 (33.9) | 16.4 (18.4) | 17.2 (18.0) | 16.0 (18.5) |
| *1/*3 | 0.4 (0.5) | 7.2 (5.9) | 0.4 (0.6) | 0.0 (0.0) | 0.0 (0.0) |
| *1/*4B | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.6) | 0.0 (0.3) | 2.0 (2.5) |
| *1/*6 | 0.0 (0.0) | 0.0 (0.0) | 0.4 (0.3) | 0.0 (0.0) | 0.0 (0.0) |
| *1/*8 | 0.0 (0.0) | 0.0 (0.0) | 0.4 (0.3) | 0.4 (0.6) | 0.0 (0.0) |
|
|
|||||
| TOTAL: | 18.8 (23.5) | 44.4 (39.8) | 17.6 (20.0) | 17.7 (18.9) | 18.0 (21.0) |
| Poor Metabolizer (PM) | |||||
| *2/*2 | 4.8 (3.8) | 6.4 (7.6) | 2.8 (1.7) | 2.0 (1.6) | 2.8 (2.1) |
| *2/*3 | 0.4 (0.2) | 1.6 (2.6) | 0.4 (0.1) | 0.0 (0.0) | 0.0 (0.0) |
| *2/*4B | 0.0 (0.0) | 0.0 (0.0) | 0.8 (0.1) | 0.0 (0.1) | 0.8 (0.6) |
| *3/*3 | 0.0 (0.0) | 0.4 (0.2) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) |
|
|
|||||
| TOTAL: | 5.2 (3.9) | 8.4 (10.5) | 4.0 (2.0) | 2.0 (1.8) | 3.6 (2.8) |
| Unknown | |||||
| *1/*9 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.4 (0.3) | 0.0 (0.0) |
| *1/*13 | 0.8 (1.4) | 0.0 (0.0) | 0.0 (0.0) | 0.8 (0.6) | 0.0 (0.0) |
| *1/*15 | 2.0 (1.7) | 0.0 (0.0) | 0.4 (0.3) | 0.8 (0.6) | 0.0 (0.0) |
| *2/*13 | 0.8 (0.5) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.1) | 0.0 (0.0) |
| *2/*15 | 0.4 (0.5) | 0.0 (0.0) | 0.0 (0.1) | 0.0 (0.1) | 0.4 (0.1) |
| *2/*17 | 9.2 (7.1) | 3.6 (3.4) | 3.2 (4.2) | 4.4 (3.9) | 6.4 (5.8) |
| *3/*17 | 0.0 (0.1) | 0.0 (0.6) | 0.0 (0.1) | 0.0 (0.0) | 0.0 (0.0) |
| *4B/*15 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.4 (0.0) |
| *4B/*17 | 0.0 (0.0) | 0.0 (0.0) | 0.0(0.1) | 0.4(0.1) | 0.8 (0.8) |
| *8/*17 | 0.4 (0.1) | 0.0 (0.0) | 0.0 (0.1) | 0.4 (0.1) | 0.0 (0.0) |
| *13/*17 | 0.8 (0.4) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.1) | 0.0 (0.0) |
| *15/*17 | 0.4 (0.5) | 0.0 (0.0) | 0.0 (0.1) | 0.0 (0.1) | 0.0 (0.2) |
|
|
|||||
| TOTAL: | 14.4 (12.3) | 3.6 (4.0) | 3.6 (4.9) | 7.2 (5.9) | 8.0 (7.4) |