TABLE 4.
CYP2C8 Genotype Frequencies
| CYP2C8 Genotype | Observed (expecteda) frequency (%) |
||||
|---|---|---|---|---|---|
| African-American (n = 248) | Asian (n = 249) | Caucasian (n = 248) | Hispanic (n = 248) | Ashkenazi Jewish (n = 249) | |
| Wild-type | |||||
| *1/*1 | 76.6 (76.9) | 92.0 (92.5) | 77.2 (75.7) | 78.6 (78.3) | 80.0 (81.0) |
| Heterozygous | |||||
| *1/*2 | 18.1 (17.7) | 0.8 (0.8) | 0.4 (0.3) | 4.0 (3.9) | 0.8 (0.7) |
| *1/*3 | 2.0 (1.8) | 4.4 (4.3) | 14.8 (16.4) | 12.9 (13.6) | 15.2 (13.7) |
| *1/*4 | 2.0 (2.1) | 2.4 (2.3) | 4.4 (5.6) | 2.8 (2.9) | 4.0 (3.6) |
| *1/*14 | 0.0 (0.0) | 0.0 (0.0) | 0.4 (0.3) | 0.0 (0.3) | 0.0 (0.0) |
|
|
|||||
| TOTAL: | 22.2 (21.6) | 7.6 (7.4) | 20.0 (22.6) | 19.8 (20.3) | 20.0 (18.0) |
| Homozygous Variant/Compound Heterozygous | |||||
| *2/*2 | 0.8 (1.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) |
| *2/*3 | 0.0 (0.2) | 0.0 (0.0) | 0.0 (0.0) | 0.4 (0.3) | 0.0 (0.1) |
| *2/*4 | 0.4 (0.2) | 0.0 (0.0) | 0.0 (0.0) | 0.0(0.1) | 0.0 (0.0) |
| *3/*3 | 0.0 (0.0) | 0.0 (0.0) | 0.8 (0.9) | 0.8 (0.6) | 0.0 (0.6) |
| *3/*4 | 0.0 (0.0) | 0.0 (0.1) | 2.0 (0.6) | 0.4 (0.3) | 0.0 (0.3) |
|
|
|||||
| TOTAL: | 0.4 (0.3) | 0.0 (0.1) | 2.8 (1.5) | 1.2 (0.9) | 0.0 (0.9) |
n: number of subjects.
a
Predicted Hardy-Weinberg frequencies.