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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Immunol Cell Biol. 2012 Apr 10;90(8):802–811. doi: 10.1038/icb.2012.17

Figure 6. IL-21 is required for IL-6-induced Ig production during T-B cell collaboration.

Figure 6

(A) Mitomycin-c–treated CD4+ T cells (1 × 105) were cultured with 1 × 105 CD19+ B cells in 0.2 ml in the presence of PHA with medium, IL-6, or IL-21 and Ig production was determined after five days by ELISA. (B) IL-6–stimulated co-cultures of T and B cells were treated for five days with either control Ig (10 μg/ml) or IL-21R:Fc fusion protein (10 μg/ml). Results are means ± SD of three independent donors. Statistical significance (***, P < 0.001) was determined using unpaired Student’s t-tests.

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