Altered Gene Expression in Cultured Microglia in Response to Simulated Blast Overpressure: Possible Role of Pulse Duration

. Author manuscript; available in PMC: 2013 Jul 26.

Published in final edited form as: Neurosci Lett. 2012 Jun 12;522(1):47–51. doi: 10.1016/j.neulet.2012.06.012

Microglial genes changed in expression by simulated blast overpressure as determined by microarray analysis

Fold-change	p value	Gene symbol	Gene Definition	Accession #
2.26	0.008^a,b	Tyki	Thymidylate kinase family, LPS inducible	NM_020557.3
2.20	0.028^a,b	Ehd1	EH-domain containing 1	NM_010119.3
2.43	0.008^a,b	Fas	TNF receptor superfamily	NM_007987.1
2.01	0.015^a,b	Parp14	poly (ADP-ribose) polymerase family14	NM_001039530.1
2.62	0.013^a,b	Cxcl10	Chemokine (C-X-C motif) ligand 10	NM_021274.1
2.81	0.008^a,b	Hp	Haptoglobin	NM_017370.1
3.70	0.032^a	Saa3	Serum amyloid A 3	NM_011315
2.94	0.028^a	Gpr84	G protein-coupled receptor 84	NM_030720.1
2.36	0.008^a,b	Usp18	ubiquitin specific peptidase 18	NM_011909.1
3.70	0.008^a,b	Irg1	Immunoresponsive gene 1	XM_127883
2.02	0.015^a,b	Gpr109a	G protein-coupled receptor 109A	NM_030701.1
2.31	0.013^a,b	Rsad2	radical S-adenosyl methionine domain containing 2	NM_021384.2
2.55	0.008^a,b	Ifit3	interferon-induced protein with tetratricopeptide repeats 3	NM_010501.1
2.20	0.015^a,b	Cd40	CD40 antigen, transcript variant 5	NM_170702.2
2.67	0.008^a,b	Clecsf9	C-type lectin domain family, member e	NM_019948.1
2.13	0.019^a,b	Tnfrsf5	TNF receptor superfamily, member 5	NM_170704.1
2.16	0.017^a,b	Tnf	Tumor necrosis factor	NM_013693

Significantly different (at indicated p values) from controls exposed to overpressure at a pulse duration of 14.25 sec.

Significantly different (at indicated p values) from cells exposed to overpressure at a pulse duration of 12 msec. No genes were changed in expression at a pulse duration of 12 msec by comparison to controls.