Table 2.

Behavior in Rhes Mutant Mice

Behavior	Effect	Reference
Open field, drug-naïve	rhes−/− locomotion ↓ 1st 5 min	Spano et al., 2004
Rotarod, drug-naïve	rhes−/− ↓latency to fall	Spano et al., 2004
Elevated plus-maze, drug-naïve	rhes−/− females ↑ anxiety	Spano et al., 2004
Morris water maze, drug-naive	no genotype difference	Spano et al., 2004
Passive avoidance, drug-naïve
Novelty-induced exploration, drug-naïve	rhes−/− ↑ activity	Errico et al., 2008
Open field, drug-naïve	rhes−/− ↑ activity	Errico et al., 2008
Rotarod, drug-naïve	no genotype difference	Errico et al., 2008
Locomotor activity, SKF 81297	rhes−/− ↑activity	Errico et al., 2008
Stereotypy, apomorphine	rhes−/−, rhes+/− ↑ response	Quintero et al., 2008
Catalepsy, haloperidol	rhes−/− ↑ response	Errico et al., 2008
Catalepsy, eticlopride	rhes−/− ↑ response	Quintero et al., 2008
Grooming, SKF 38393	rhes−/− ↓ response	Quintero et al., 2008
Tail flick analgesia, morphine	rhes−/− ↑ analgesia	Lee et al., 2011
Formalin analgesia, morphine	rhes−/− ↑ analgesia	Lee et al., 2011
Morphine analgesia tolerance	rhes−/− no tolerance	Lee et al., 2011
Opiate withdrawal (naloxone-precipitated)	rhes−/− ↓ response	Lee et al., 2011