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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Semin Cell Dev Biol. 2012 Mar 30;23(7):729–737. doi: 10.1016/j.semcdb.2012.03.014

Figure 3. Association of GSH/GSSG, Cys/CySS and Trx/TrSS redox potential (Eh) with normal intestinal phenotypic transitions.

Figure 3

Under physiological conditions, intestinal cell transition from proliferation to differentiation or apoptosis is associated with quantitative changes in the Eh of the GSH/GSSG or Cys/CySS redox couples. A 40mV oxidation in intracellular GSH/GSSG Eh elicits cell transition from a proliferative to differentiated, non dividing state. The apoptotic or necrotic states result from an additional 50mV or 70mV oxidation. Additionally, intestinal cell progression from proliferation to differentiation is accompanied by ~ 30mV oxidation of the Eh of extracellular/intracellular Cys/CySS redox couple. Cell transition is unrelated to the Eh of the Trx/TrxS redox couple. A role for extracellular GSH/GSSG in intestinal phenotypic change is unknown.