Table 1.
Characteristics of the Study Population by HBV Screening Status
| Characteristic | Total (N = 10,729) |
HBV Screening |
||||
|---|---|---|---|---|---|---|
| Yes (n = 1,787) |
No (n = 8,942) |
|||||
| No. | % | No. | % | No. | % | |
| Age, years | ||||||
| Mean | 54.9 | 51.5 | 55.5 | |||
| SD | 13.8 | |||||
| Sex | ||||||
| Male | 4,866 | 45.4 | 1,060 | 21.8 | 3,806 | 78.2 |
| Female | 5,863 | 55.6 | 727 | 12.4 | 5,136 | 87.6 |
| Ethnicity | ||||||
| White | 7,810 | 72.8 | 1,310 | 16.8 | 6,500 | 83.2 |
| Hispanic | 1,279 | 11.9 | 230 | 18.0 | 1,049 | 82.0 |
| Black | 1,138 | 10.6 | 139 | 12.2 | 999 | 87.8 |
| Asian | 266 | 2.5 | 45 | 16.9 | 221 | 83.1 |
| Other | 236 | 2.2 | 63 | 26.7 | 173 | 73.3 |
| US residence | 10,428 | 97.2 | 1,716 | 16.5 | 8,712 | 83.5 |
| History of HBV infection* | 95 | 0.9 | 65 | 68.4 | 30 | 31.6 |
| HBV risk factors† | 2,612 | 24.3 | 513 | 19.6 | 2,099 | 80.4 |
| Cancer type | ||||||
| Solid tumor | 9,009 | 84.0 | 555 | 6.2 | 8,454 | 93.8 |
| Hematologic malignancy | 1,720 | 16.0 | 1,232 | 71.6 | 488 | 28.4 |
| Chemotherapy type | ||||||
| Chemotherapy/nonimmunotherapy | 8,315 | 77.5 | 887 | 10.7 | 7,428 | 89.3 |
| Immunotherapy, excluding rituximab | 1,293 | 12.1 | 100 | 7.7 | 1,193 | 92.3 |
| Rituximab | 1,121 | 10.4 | 800 | 71.4 | 321 | 28.6 |
NOTE. HBV screening refers to either HBsAg or anti-HBc screening test ordered; all comparisons between screened and unscreened patients are statistically significant using χ2 test (P < .001).
Abbreviations: anti-HBc, antibody to hepatitis B core antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; ICD-9, International Classification of Diseases, version 9; SD, standard deviation.
Patients who had an ICD-9 code for hepatitis B (070.2, 070.3, 070.20, 070.21, 070.22, 070.23, 070.310, 070.31, 070.32, 070.33, or v02.61) entered before HBV screening were considered to have a history of HBV infection.
Patients with at least one of the following ICD-9 diagnoses codes entered into the database anytime before HBV screening were considered to have a risk factor for HBV infection: (A) hepatitis, not specific (codes 070, 070.4, 070.49, 070.5, 070.59, 070.6, 070.9, 571.4, 571.40, 571.41, 571.42, 571.49, 573.1, 573.2, 573.3, v02.6, v02.60, and v02.69); (B) other liver conditions (codes 571, 571.0, 571.0, 571.2, 571.3, 571.5, 571.6, 571.8, 571.9, 572, 572.0, 572.8, 573, 573.8, 573.9, 782.4, 789.1, and 794.8); (C) hepatitis C (codes 070.41, 070.44, 070.51, 070.54, 070.7, 070.70, 070.71, and v02.62); and (D) human immunodeficiency disease (codes 042, 042.0, 042.1, 042.2, 043, 043.0, 043.1, 043.2, 043.3, 044.0, 044.9, 079.53, 795.71, 795.8, v08, and v65.44).